In the context of contemporary Globalization, the regional unit of analysis has become a category of analysis. Regions constitute nowadays a fundamental category for political, economic, social and cultural analysis, but it is important to take into account that the definition of a region must be made from a complex perspective which involves its structural, as well as its constructivist and social representation dimension. Taken as a category of analysis, in this article we carry out a discussion on the region's dimensions -as a social, spatial, political, historical and subjective construction- in order to propose a model of conceptual-relational analysis which enables us to deal with the regional history of Latin America in a more integral way -by establishing links between History and Geography- and from an interdisciplinary and trans-areal perspective. By encouraging the study of the border and trans-border, as well as the local, the national and the transnational condition, the aim is to get over the geopolitical rigidity of the area studies made in the Anglo-Saxon world.