ORALLY-ACTIVE NONPEPTIDE FIBRINOGEN RECEPTOR (GPIIB/IIIA) ANTAGONISTS - IDENTIFICATION OF 4-[4-[4-(AMINOIMINOMETHYL)PHENYL]-1-PIPERAZINYL]-1-PIPERIDINEACETIC ACID AS A LONG-ACTING, BROAD-SPECTRUM ANTITHROMBOTIC AGENT

被引：48

作者：

ELDRED, CD ^{[1
]}

EVANS, B ^{[1
]}

HINDLEY, S ^{[1
]}

JUDKINS, BD ^{[1
]}

KELLY, HA ^{[1
]}

KITCHIN, J ^{[1
]}

LUMLEY, P ^{[1
]}

PORTER, B ^{[1
]}

ROSS, BC ^{[1
]}

SMITH, KJ ^{[1
]}

TAYLOR, NR ^{[1
]}

WHEATCROFT, JR ^{[1
]}

机构：

[1] GLAXO RES & DEV LTD,DEPT CELLULAR SCI,WARE SG12 0DP,HERTS,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 23期

关键词：

D O I：

10.1021/jm00049a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3882 / 3885

页数：4

共 27 条

[1] BENZYLAMINE ANALOGUES OF CHEMOTHERAPEUTIC DIAMIDINES
ALBERT, A
MILLS, JA
ROYER, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1947, (NOV): : 1452 - 1455
[2] LOW-MOLECULAR-WEIGHT, NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS
ALIG, L
EDENHOFER, A
HADVARY, P
HURZELER, M
KNOPP, D
MULLER, M
STEINER, B
TRZECIAK, A
WELLER, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) : 4393 - 4407
[3] CYCLIC RGD PEPTIDE ANALOGS AS ANTIPLATELET ANTITHROMBOTICS
BARKER, PL
BULLENS, S
BUNTING, S
BURDICK, DJ
CHAN, KS
DEISHER, T
EIGENBROT, C
GADEK, TR
GANTZOS, R
LIPARI, MT
MUIR, CD
NAPIER, MA
PITTI, RM
PADUA, A
QUAN, C
STANLEY, M
STRUBLE, M
TOM, JYK
BURNIER, JP
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) : 2040 - 2048
[4] BARKER PL, 1993, CHEMTRACTS ORG CHEM, V6, P42
[5] A MONOCLONAL-ANTIBODY AGAINST THE PLATELET GLYCOPROTEIN-IIB/IIIA RECEPTOR COMPLEX PREVENTS PLATELET-AGGREGATION AND THROMBOSIS IN A CANINE MODEL OF CORONARY ANGIOPLASTY
BATES, ER
MCGILLEM, MJ
MICKELSON, JK
PITT, B
MANCINI, GBJ
[J]. CIRCULATION, 1991, 84 (06) : 2463 - 2469
[6] DESIGN AND SYNTHESIS OF A C-7 MIMETIC FOR THE PREDICTED GAMMA-TURN CONFORMATION FOUND IN SEVERAL CONSTRAINED RGD ANTAGONISTS
CALLAHAN, JF
BEAN, JW
BURGESS, JL
EGGLESTON, DS
HWANG, SM
KOPPLE, KD
KOSTER, PF
NICHOLS, A
PEISHOFF, CE
SAMANEN, JM
VASKO, JA
WONG, A
HUFFMAN, WF
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (21) : 3970 - 3972
[7] THE USE OF GAMMA-TURN MIMETICS TO DEFINE PEPTIDE SECONDARY STRUCTURE
CALLAHAN, JF
NEWLANDER, KA
BURGESS, JL
EGGLESTON, DS
NICHOLS, A
WONG, A
HUFFMAN, WF
[J]. TETRAHEDRON, 1993, 49 (17) : 3479 - 3488
[8] COLLER BS, 1986, BLOOD, V68, P783
[9] Cook Nigel S., 1994, Drugs of the Future, V19, P135
[10] FOSTER MR, 1993, THROMB HAEMOSTASIS, V69, P559

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