THE MODULATION OF FERRYL MYOGLOBIN FORMATION AND ITS OXIDATIVE EFFECTS ON LOW-DENSITY LIPOPROTEINS BY NITRIC-OXIDE

被引：89

作者：

DEE, G

RICEEVANS, C

OBEYESEKERA, S

MERAJI, S

JACOBS, M

BRUCKDORFER, KR

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,DIV BIOCHEM,LAMBETH PALACE RD,LONDON SE1 7EH,ENGLAND

[2] ROYAL FREE HOSP,SCH MED,DEPT BIOCHEM,LONDON NW3 2PF,ENGLAND

[3] ROYAL FREE HOSP,SCH MED,DEPT PHARMACOL,LONDON NW3 2PF,ENGLAND

来源：

FEBS LETTERS | 1991年 / 294卷 / 1-2期

基金：

英国惠康基金;

关键词：

FERRYL MYOGLOBIN SPECIES; METMYOGLOBIN; LDL; LIPID PEROXIDATION; NITRIC OXIDE;

D O I：

10.1016/0014-5793(91)81338-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study has investigated the interactions between nitric oxide and haem protein radicals. The results demonstrate that nitric oxide interacts with activated ferryl myoglobin species with reduction to metmyoglobin, but the extent and duration of the reduction depends on the relative concentrations of nitric oxide and hydrogen peroxide. Ferryl myoglobin has a much greater relative potential for oxidising polyunsaturated fatty acid side chains in low density lipoproteins than in cell membranes. The peroxidative response can be modulated by nitric oxide: ferryl myoglobin-mediated peroxidation of LDL may be enhanced or suppressed by nitric oxide depending on the relative concentrations of NO and hydrogen peroxide.

引用

页码：38 / 42

页数：5

共 24 条

[1] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].