George Eliopoulos is a member of the Infectious Diseases Division at the Deaconess Hospital in Boston, where he also serves as the program director for the residency program in Internal Medicine. His research interests have included bacterial resistance mechanisms in general, and antimicrobial resistance among enterococci in particular. When he entered the field, high-level gentamicin resistance in enterococci had just been documented. Many of the problems described in this piece have emerged since that time. The author scrupulously notes his belief that opinion pieces such as this can be a vector for the transmission of subtle biases and that he has no equity interests in any of the companies manufacturing agents discussed in this article but has received grant support or honoraria from several of these.