TOREMIFENE RESISTANCE IN A RAT MAMMARY-TUMOR MODEL

被引:0
|
作者
KELLEN, JA [1 ]
GEORGES, E [1 ]
LING, V [1 ]
DUBSKY, M [1 ]
机构
[1] ONTARIO CANC INST,TORONTO M4X 1K9,ONTARIO,CANADA
关键词
ANTIESTROGENS; TAMOXIFEN; TOREMIFENE; CROSS-RESISTANCE; P-GLYCOPROTEIN;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of Toremifene on cell growth in vitro was tested on the R3230AC rat mammary adenocarcinoma as model. Toremifene differed from Tamoxifen in that it did not induce resistance; some cross-resistance was observed in Tamoxifen tolerant tumour cell lines. Toremifene does not influence P-glycoprotein expression in this model and at the levels studied.
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页码:1663 / 1665
页数:3
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