STRUCTURE-ACTIVITY-RELATIONSHIPS OF POLYMETHOXYFLAVONES AND OTHER FLAVONOIDS AS INHIBITORS OF NONENZYMATIC LIPID-PEROXIDATION

被引：276

作者：

MORA, A ^{[1
]}

PAYA, M ^{[1
]}

RIOS, JL ^{[1
]}

ALCARAZ, MJ ^{[1
]}

机构：

[1] FAC FARM VALENCIA,DEPT FARMACOL & FARMACOTEC,AVDA BLASCO IBANEZ 13,E-46010 VALENCIA,SPAIN

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 40卷 / 04期

关键词：

D O I：

10.1016/0006-2952(90)90317-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymethoxylated flavones and C-glycosyl derivatives isolated from medicinal plants besides other flavonoid compounds were studied for their influence on lipid peroxidation induced by FeSO4+cysteine in rat liver microsomes. A number of hydroxyflavones (e.g. luteolin); C-glycosyl-flavones (e.g. orientin); methoxyflavones (e.g. gardenin D) and flavonols (e.g. datiscetin), as well as the flavanol leucocyanidol and the biflavone amentoflavone behaved as inhibitors of non-enzymic lipid peroxidation. Structure-activity relationships were established and it was observed that the structural features for active polyhydroxylated compounds were different from those of polymethoxylated flavones, antiperoxidative flavonoids possessing a high lipophilicity. © 1990.

引用

页码：793 / 797

页数：5

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