STRUCTURE-ACTIVITY-RELATIONSHIPS OF POLYMETHOXYFLAVONES AND OTHER FLAVONOIDS AS INHIBITORS OF NONENZYMATIC LIPID-PEROXIDATION

被引：273
作者：
MORA, A [1 ]
PAYA, M [1 ]
RIOS, JL [1 ]
ALCARAZ, MJ [1 ]
机构：
[1] FAC FARM VALENCIA,DEPT FARMACOL & FARMACOTEC,AVDA BLASCO IBANEZ 13,E-46010 VALENCIA,SPAIN
来源：
BIOCHEMICAL PHARMACOLOGY | 1990年 / 40卷 / 04期
关键词：
D O I：
10.1016/0006-2952(90)90317-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Polymethoxylated flavones and C-glycosyl derivatives isolated from medicinal plants besides other flavonoid compounds were studied for their influence on lipid peroxidation induced by FeSO4+cysteine in rat liver microsomes. A number of hydroxyflavones (e.g. luteolin); C-glycosyl-flavones (e.g. orientin); methoxyflavones (e.g. gardenin D) and flavonols (e.g. datiscetin), as well as the flavanol leucocyanidol and the biflavone amentoflavone behaved as inhibitors of non-enzymic lipid peroxidation. Structure-activity relationships were established and it was observed that the structural features for active polyhydroxylated compounds were different from those of polymethoxylated flavones, antiperoxidative flavonoids possessing a high lipophilicity. © 1990.
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页码：793 / 797
页数：5
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