An Adult Patient with Systemic Mastocytosis and B-Acute Lymphoblastic Leukemia

被引：3

作者：

Iliakis, Theodoros ^{[1
]}

Rougkala, Niki ^{[1
]}

Diamantopoulos, Panagiotis T. ^{[1
]}

Papadopoulou, Vasiliki ^{[1
]}

Kalala, Fani ^{[1
]}

Zervakis, Konstantinos ^{[1
]}

Giannakopoulou, Nefeli ^{[1
]}

Chatzinikolaou, Polixeni ^{[1
]}

Levidou, Georgia ^{[2
]}

Lakiotaki, Eleftheria ^{[2
]}

Korkolopoulou, Penelope ^{[2
]}

Patsouris, Efstratios ^{[2
]}

Variami, Eleni ^{[1
]}

Viniou, Nora-Athina ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Internal Med 1, Hematol Unit, 17 AgiouThoma St, Athens 11527, Greece

[2] Natl & Kapodistrian Univ Athens, Dept Pathol, Athens, Greece

来源：

CASE REPORTS IN MEDICINE | 2014年 / 2014卷

关键词：

D O I：

10.1155/2014/526129

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mastocytosis is a myeloproliferative neoplasm characterized by clonal expansion of abnormal mast cells, ranging from the cutaneous forms of the disease to mast cell leukemia. In a significant proportion of patients, systemic mastocytosis (SM) coexists with another hematologic malignancy, termed systemic mastocytosis with an associated hematologic nonmast cell lineage disorder (SM-AHNMD). Despite the pronounced predominance of concomitant myeloid neoplasms, the much more unusual coexistence of lymphoproliferative diseases has also been reported. Imatinib mesylate (IM) has a role in the treatment of SM in the absence of the KITD816 Vmutation. In the setting of SM-AHNMD, eradicating the nonmast cell malignant clone greatly affects prognosis. We report a case of an adult patient with SM associated with B-lineage acute lymphoblastic leukemia (B-ALL). Three cases of concurrent adult ALL and mastocytosis have been reported in the literature, one concerning SM and two concerning cutaneous mastocytosis (CM), as well as six cases of concomitant CM and ALL in children.

引用

页数：5

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