Draft genome sequence of the docosahexaenoic acid producing thraustochytrid Aurantiochytrium sp. T66

被引：34

作者：

Liu, Bin ^{[1
]}

Ertesvag, Helga ^{[1
]}

Aasen, Inga Marie ^{[2
]}

Vadstein, Olav ^{[1
]}

Brautaset, Trygve ^{[1
,2
]}

Heggeset, Tonje Marita Bjerkan ^{[2
]}

机构：

[1] NTNU Norwegian Univ Sci & Technol, Dept Biotechnol, Trondheim, Norway

[2] SINTEF Mat & Chem, Dept Biotechnol & Nanomed, Postboks 4760 Sluppen, N-7465 Trondheim, Norway

来源：

GENOMICS DATA | 2016年 / 8卷

关键词：

Thraustochytrid; Aurantiochytrium; Whole genome sequencing; Docosahexaenoic acid;

D O I：

10.1016/j.gdata.2016.04.013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Thraustochytrids are unicellular, marine protists, and there is a growing industrial interest in these organisms, particularly because some species, including strains belonging to the genus Aurantiochytrium, accumulate high levels of docosahexaenoic acid (DHA). Here, we report the draft genome sequence of Aurantiochytrium sp. T66 (ATCC PRA-276), with a size of 43 Mbp, and 11,683 predicted protein-coding sequences. The data has been deposited at DDBJ/EMBL/Genbank under the accession LNGJ00000000. The genome sequence will contribute new insight into DHA biosynthesis and regulation, providing a basis for metabolic engineering of thraustochytrids. (C) 2016 The Authors. Published by Elsevier Inc.

引用

页码：115 / 116

页数：2

共 21 条

[1] Thraustochytrids as production organisms for docosahexaenoic acid (DHA), squalene, and carotenoids [J].

Aasen, Inga Marie ;

Ertesvag, Helga ;

Heggeset, Tonje Marita Bjerkan ;

Liu, Bin ;

Brautaset, Trygve ;

Vadstein, Olav ;

Ellingsen, Trond E. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 100 (10) :4309-4321

[2]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[3] The DIAMOND (DHA Intake And Measurement Of Neural Development) Study: a double-masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of docosahexaenoic acid [J].

Birch, Eileen E. ;

Carlson, Susan E. ;

Hoffman, Dennis R. ;

Fitzgerald-Gustafson, Kathleen M. ;

Fu, Valeria L. N. ;

Drover, James R. ;

Castaneda, Yolanda S. ;

Minns, Laura ;

Wheaton, Dianna K. H. ;

Mundy, David ;

Marunycz, John ;

Diersen-Schade, Deborah A. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (04) :848-859

[4] GeneWise and genomewise [J].

Birney, E ;

Clamp, M ;

Durbin, R .

GENOME RESEARCH, 2004, 14 (05) :988-995

[5] Trimmomatic: a flexible trimmer for Illumina sequence data [J].

Bolger, Anthony M. ;

Lohse, Marc ;

Usadel, Bjoern .

BIOINFORMATICS, 2014, 30 (15) :2114-2120

[6] The differential effects of EPA and DHA on cardiovascular risk factors [J].

Cottin, S. C. ;

Sanders, T. A. ;

Hall, W. L. .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2011, 70 (02) :215-231

[7] Development of Genomic Resources for a thraustochytrid Pathogen and Investigation of Temperature Influences on Gene Expression [J].

Garcia-Vedrenne, Ana Elisa ;

Groner, Maya ;

Page-Karjian, Annie ;

Siegmund, Gregor-Fausto ;

Singhal, Sonia ;

Sziklay, Jamie ;

Roberts, Steven .

PLOS ONE, 2013, 8 (09)

[8] Accumulation of docosahexaenoic acid-rich lipid in thraustochytrid Aurantiochytrium sp strain T66:: effects of N and P starvation and O2 limitation [J].

Jakobsen, Anita N. ;

Aasen, Inga M. ;

Josefsen, Kjell D. ;

Strom, Arne R. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 80 (02) :297-306

[9] Endogenously synthesized (-)-proto-quercitol and glycine betaine are principal compatible solutes of Schizochytrium sp strain S8 (ATCC 20889) and three new isolates of phylogenetically related thraustochytrids [J].

Jakobsen, Anita N. ;

Aasen, Inga M. ;

Strom, Arne R. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (18) :5848-5856

[10]

Ji X.J., 2015, GENOME ANNOUNC, V3

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