LINKAGE ANALYSIS OF 26 CANADIAN BREAST AND BREAST-OVARIAN CANCER FAMILIES

被引：0

作者：

TONIN, P

MOSLEHI, R

GREEN, R

ROSEN, B

COLE, D

BOYD, N

CUTLER, C

MARGOLESE, R

CARTER, R

MCGILLIVRAY, B

IVES, E

LABRIE, F

GILCHRIST, D

MORGAN, K

SIMARD, J

NAROD, SA

机构：

[1] MCGILL UNIV, DEPT MED, DIV MED GENET, MONTREAL, PQ H3G 1A4, CANADA

[2] MCGILL UNIV, DEPT HUMAN GENET, MONTREAL, PQ H3G 1A4, CANADA

[3] UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

[4] MEM UNIV NEWFOUNDLAND, FAC MED, St John, NF, CANADA

[5] TORONTO HOSP, DEPT OBSTET & GYNECOL, TORONTO, ON M5T 2S8, CANADA

[6] TORONTO HOSP, DEPT BIOCHEM, TORONTO, ON M5T 2S8, CANADA

[7] ONTARIO CANC INST, DEPT BIOSTAT & EPIDEMIOL, TORONTO, ON M4X 1K9, CANADA

[8] JEWISH GEN HOSP, DEPT SURG, MONTREAL, PQ, CANADA

[9] MCMASTER UNIV, DEPT PATHOL, HAMILTON, ON, CANADA

[10] CHUL, RES CTR, MRC, MOLEC ENDOCRINOL GRP, QUEBEC CITY, PQ, CANADA

[11] UNIV LAVAL, QUEBEC CITY, PQ, CANADA

[12] UNIV ALBERTA, DEPT MED, EDMONTON, AB, CANADA

来源：

HUMAN GENETICS | 1995年 / 95卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12-q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a placement of BRCA1 telomeric to D17S776, and helps to define the region of assignment of the cancer susceptibility gene. Other cancers of interest that appeared in the BRCA1-linked families included primary peri-toneal cancer, cancer of the fallopian tube, and malignant melanoma.

引用

页码：545 / 550

页数：6

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