LINKAGE ANALYSIS OF 26 CANADIAN BREAST AND BREAST-OVARIAN CANCER FAMILIES

被引：0

作者：

TONIN, P

MOSLEHI, R

GREEN, R

ROSEN, B

COLE, D

BOYD, N

CUTLER, C

MARGOLESE, R

CARTER, R

MCGILLIVRAY, B

IVES, E

LABRIE, F

GILCHRIST, D

MORGAN, K

SIMARD, J

NAROD, SA

机构：

[1] MCGILL UNIV, DEPT MED, DIV MED GENET, MONTREAL, PQ H3G 1A4, CANADA

[2] MCGILL UNIV, DEPT HUMAN GENET, MONTREAL, PQ H3G 1A4, CANADA

[3] UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA

[4] MEM UNIV NEWFOUNDLAND, FAC MED, St John, NF, CANADA

[5] TORONTO HOSP, DEPT OBSTET & GYNECOL, TORONTO, ON M5T 2S8, CANADA

[6] TORONTO HOSP, DEPT BIOCHEM, TORONTO, ON M5T 2S8, CANADA

[7] ONTARIO CANC INST, DEPT BIOSTAT & EPIDEMIOL, TORONTO, ON M4X 1K9, CANADA

[8] JEWISH GEN HOSP, DEPT SURG, MONTREAL, PQ, CANADA

[9] MCMASTER UNIV, DEPT PATHOL, HAMILTON, ON, CANADA

[10] CHUL, RES CTR, MRC, MOLEC ENDOCRINOL GRP, QUEBEC CITY, PQ, CANADA

[11] UNIV LAVAL, QUEBEC CITY, PQ, CANADA

[12] UNIV ALBERTA, DEPT MED, EDMONTON, AB, CANADA

来源：

HUMAN GENETICS | 1995年 / 95卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12-q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a placement of BRCA1 telomeric to D17S776, and helps to define the region of assignment of the cancer susceptibility gene. Other cancers of interest that appeared in the BRCA1-linked families included primary peri-toneal cancer, cancer of the fallopian tube, and malignant melanoma.

引用

页码：545 / 550

页数：6

共 18 条

[1]

COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252

[2]

EASTON DF, 1993, AM J HUM GENET, V52, P678

[3]

FEUNTEUN J, 1993, AM J HUM GENET, V52, P736

[4] RISKS OF CANCER IN BRCA1-MUTATION CARRIERS [J].

FORD, D ;

EASTON, DF ;

BISHOP, DT ;

NAROD, SA ;

GOLDGAR, DE ;

HAITES, N ;

MILNER, B ;

ALLAN, L ;

PONDER, BAJ ;

PETO, J ;

SMITH, S ;

STRATTON, M ;

LENOIR, GM ;

FEUNTEUN, J ;

LYNCH, H ;

ARASON, A ;

BARKARDOTTIR, R ;

EGILSSON, V ;

BLACK, DM ;

KELSELL, D ;

SPURR, N ;

DEVILEE, P ;

CORNELISSE, CJ ;

VARSEN, H ;

BIRCH, JM ;

SKOLNICK, M ;

SANTIBANEZKOREF, MS ;

TEARE, D ;

STEEL, M ;

PORTER, D ;

COHEN, BB ;

CAROTHERS, A ;

SMYTH, E ;

WEBER, B ;

NEWBOLD, B ;

BOEHNKE, M ;

COLLINS, FS ;

CANNONALBRIGHT, LA ;

GOLDGAR, D .

LANCET, 1994, 343 (8899) :692-695

[5] A LARGE KINDRED WITH 17Q-LINKED BREAST AND OVARIAN-CANCER - GENETIC, PHENOTYPIC, AND GENEALOGICAL ANALYSIS [J].

GOLDGAR, DE ;

FIELDS, P ;

LEWIS, CM ;

TRAN, TD ;

CANNONALBRIGHT, LA ;

WARD, JH ;

SWENSEN, J ;

SKOLNICK, MH .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (03) :200-209

[6] LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21 [J].

HALL, JM ;

LEE, MK ;

NEWMAN, B ;

MORROW, JE ;

ANDERSON, LA ;

HUEY, B ;

KING, MC .

SCIENCE, 1990, 250 (4988) :1684-1689

[7] OVARIAN-CANCER .1. BIOLOGY [J].

HAMILTON, TC .

CURRENT PROBLEMS IN CANCER, 1992, 16 (01) :5-57

[8]

LATHROP GM, 1984, AM J HUM GENET, V36, P460

[9]

LINDBLOM A, 1993, AM J HUM GENET, V52, P749

[10]

MAZOYER S, 1993, AM J HUM GENET, V52, P754

← 1 2 →