IMMUNE-RESPONSE OF ELDERLY INDIVIDUALS TO A LIVE ATTENUATED VARICELLA VACCINE

被引:118
作者
LEVIN, MJ
MURRAY, M
ROTBART, HA
ZERBE, GO
WHITE, CJ
HAYWARD, AR
机构
[1] UNIV COLORADO, SCH MED, DEPT MED, DENVER, CO 80262 USA
[2] UNIV COLORADO, SCH MED, DEPT MICROBIOL & IMMUNOL, DENVER, CO 80262 USA
[3] UNIV COLORADO, SCH MED, DEPT PREVENT MED & BIOMETR, DENVER, CO 80262 USA
[4] MERCK SHARP & DOHME LTD, West Point, PA 19486 USA
关键词
D O I
10.1093/infdis/166.2.253
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The Oka strain live attenuated varicella-zoster virus (VZV) vaccine was administered subcutaneously to 202 VZV-immune individuals who were 55 to >87 years old. The dose administered varied from 1100 to 12,000 pfu. One cohort received 3000 pfu with a 3000 pfu booster 3 months later. The vaccine was well tolerated. VZV-specific immunologic responses were evaluated over a 24-month period. The mean anti-VZV antibody level was significantly increased for 12 months after vaccination. Interferon-gamma production in vitro by peripheral blood mononuclear cells (PBMC) of vaccinees was also increased for 6 months after vaccination. Most significantly, VZV-specific proliferating T cells in PBMC of vaccinees were increased in frequency from 1 in 68,000 to 1 in 40,000. This vaccine-enhanced frequency of VZV-responding T cells is similar to the frequency observed in 35- to 40-year-old adults. Dose and age of the vaccinees did not significantly influence the magnitude of the mean cell-mediated immune response. The data indicate that VZV immunity in the elderly can be boosted by active immunization. If the increased incidence of herpes zoster that accompanies aging results from the natural waning of immunity, active immunization may prevent or attenuate zoster in the elderly.
引用
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页码:253 / 259
页数:7
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