A STUDY OF PATERNAL AGE AND SEX-RATIO IN SPERM CHROMOSOME COMPLEMENTS

被引：12

作者：

MARTIN, R

RADEMAKER, AW

机构：

[1] UNIV CALGARY,DEPT PEDIAT,DIV MED GENET,CALGARY T2N 1N4,ALBERTA,CANADA

[2] ALBERTA CHILDRENS PROV GEN HOSP,MED GENET CLIN,CALGARY,ALBERTA,CANADA

[3] NORTHWESTERN UNIV,SCH MED,CHICAGO,IL 60611

来源：

HUMAN HEREDITY | 1992年 / 42卷 / 06期

关键词：

SPERM CHROMOSOMES; SEX RATIO; PATERNAL AGE;

D O I：

10.1159/000154095

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is conflicting evidence as to whether the secondary sex ratio in humans decreases with paternal age. Such an age effect could be caused by an altered frequency in the production of X-chromosome and Y-chromosome-bearing sperm as a man ages. To study this possibility we analysed 9,225 sperm karyo-types from 143 men aged 21-55 years. Human pronuclear sperm chromosome complements were obtained after fusion with golden hamster oocytes. The percentage of X- and Y-chromosome complements was not significantly related to donor age.

引用

页码：333 / 336

页数：4

共 23 条

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