EXOPEPTIDASES IN HUMAN PLATELETS - AN INDICATION FOR PROTEOLYTIC MODULATION OF BIOLOGICALLY-ACTIVE PEPTIDES

被引：10
|
作者：
SCHARPE, SL [1 ]
VANHOOF, GC [1 ]
DEMEESTER, IA [1 ]
HENDRIKS, DF [1 ]
VANSANDE, ME [1 ]
MUYLLE, LM [1 ]
YARON, A [1 ]
机构：
[1] WEIZMANN INST SCI,DEPT BIOPHYS,IL-76100 REHOVOT,ISRAEL
来源：
CLINICA CHIMICA ACTA | 1991年 / 195卷 / 03期
关键词：
AMINOPEPTIDASE-P; ANGIOTENSIN CONVERTING ENZYME; CARBOXYPEPTIDASE-N; DIPEPTIDYL PEPTIDASE-IV; PLATELETS; PROLINE;
D O I：
10.1016/0009-8981(91)90132-V
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The determination in human platelets of four exopeptidases - aminopeptidase P, dipeptidyl peptidase IV, carboxypeptidase N, and angiotensin converting enzyme - by means of fluorometric or liquid chromatography techniques was carried out. The results obtained show that the specific activities of dipeptidyl peptidase IV, carboxy-peptidase N, and angiotensin converting enzyme in intact and disrupted platelets are small compared to their specific activities in serum. However, for aminopeptidase P the specific activity of this enzyme is much higher in platelets than in serum. This suggests that circulating platelets may have a significant role as scavengers for circulating peptides containing bonds susceptible for aminopeptidase P.
引用
收藏
页码：125 / 132
页数：8
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