ACYCLIC STEREOSELECTION .54. EXTENDING THE SCOPE OF THE EVANS ASYMMETRIC ALDOL REACTION - PREPARATION OF ANTI-ALDOLS AND NON-EVANS SYN-ALDOLS

被引：227

作者：

WALKER, MA ^{[1
]}

HEATHCOCK, CH ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 20期

关键词：

D O I：

10.1021/jo00020a006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Evans reagent, imide 1, reacts with aldehydes under Lewis acid catalysis to give anti or ''non-Evans'' syn aldols 5 or 6, depending on the reaction conditions. This discovery considerably amplifies the synthetic utility of these important reagents for asymmetric synthesis.

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页码：5747 / 5750

页数：4

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