SYNTHESES OF 3'-SUBSTITUTED-2-(CARBOXYCYCLOPROPYL)GLYCINES VIA INTRAMOLECULAR CYCLOPROPANATION - THE FOLDED FORM OF L-GLUTAMATE ACTIVATES THE NON-NMDA RECEPTOR SUBTYPE

被引：30

作者：

SHIMAMOTO, K ^{[1
]}

OHFUNE, Y ^{[1
]}

机构：

[1] SUNTORY INST BIOORGAN RES,SHIMAMOTO,OSAKA 618,JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)94496-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four stereoisomers of 3′-methoxymethyl-L-2-(carboxycyclopropyl)glycines, conformationally constrained analogues of L-glutamate, were synthesized in a stereoselective manner from D-serinal derivative. Selective activation of either the NMDA or Non-NMDA receptor by these isomers was observed. © 1990.

引用

页码：4049 / 4052

页数：4

共 14 条

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