MAPPING OF 2 PHENOL SULFOTRANSFERASE GENES, STP AND STM, TO 16P - CANDIDATE GENES FOR BATTEN-DISEASE

被引：37

作者：

DOOLEY, TP

MITCHISON, HM

MUNROE, PB

PROBST, P

NEAL, M

SICILIANO, MJ

DENG, ZM

DOGGETT, NA

CALLEN, DF

GARDINER, RM

MOLE, SE

机构：

[1] UNIV LONDON,SCH MED,RAYNE INST,DEPT PAEDIAT,LONDON WC1E 6JJ,ENGLAND

[2] SW FDN BIOMED RES,DEPT GENET,SAN ANTONIO,TX

[3] MD ANDERSON CANC CTR,DEPT MOLEC GENET,HOUSTON,TX

[4] LOS ALAMOS NATL LAB,DIV LIFE SCI,LOS ALAMOS,NM

[5] LOS ALAMOS NATL LAB,CTR HUMAN GENOME STUDIES,LOS ALAMOS,NM 87545

[6] ADELAIDE CHILDRENS HOSP INC,DEPT CYTOGENET & MOLEC GENET,ADELAIDE,SA,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2691

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytosolic phenol sulphotransferase gene (STP) was mapped to a region of chromosome 16, within the interval defined by human-rodent somatic cell hybrid breakpoints CY160(D) and CY12, which contains FRA16E. YAC and cosmid clones from this 16p interval were screened for the presence of STP. Two non-overlapping cosmid contigs were identified which contain STP-like sequences. Sequencing of these STP-like sequences confirmed that STP is contained within contig 343.1 and maps proximal to FRA16E, and that a related sulphotransferase STM,encoding the catecholamine-sulphating enzyme, is contained within contig 55.4 and maps to the adjacent hybrid interval CY12-CY180A. Thus two phenol sulphotransferase genes (STP and STM) have been finely localised to chromosome 16p12.1-p11.2, to the same region as CLN3, the gene for Batten disease. Both genes are therefore candidate genes for Batten disease. (C) 1994 Academic Press, Inc.

引用

页码：482 / 489

页数：8