ISATIN OXIMES - A NOVEL SERIES OF BIOAVAILABLE NON-NMDA ANTAGONISTS

被引：25

作者：

WATJEN, F

NIELSEN, EO

DREJER, J

JENSEN, LH

机构：

[1] Neurosearch A/S, DK-2600 Glostrup

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80101-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New isatin oximes are shown to be highly selective AMPA/kainate antagonists showing no antagonism of NMDA responses. In an AMPA seizure model in mice one of the disclosed compounds has anticonvulsant effects both after i.v. and p.o. dosing.

引用

页码：105 / 106

页数：2

共 5 条

[1] QUANTITATIVE STUDIES ON SOME ANTAGONISTS OF N-METHYL D-ASPARTATE IN SLICES OF RAT CEREBRAL-CORTEX [J].

HARRISON, NL ;

SIMMONDS, MA .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 84 (02) :381-391

[2] CALCIUM DISCRIMINATES 2 [H-3] KAINATE BINDING-SITES WITH DIFFERENT MOLECULAR TARGET SIZES IN RAT CORTEX [J].

HONORE, T ;

DREJER, J ;

NIELSEN, M .

NEUROSCIENCE LETTERS, 1986, 65 (01) :47-52

[3]

SUMPTER WC, 1944, CHEM REV, P393

[4] GLUTAMATE-INDUCED INCREASE IN INTRACELLULAR CA-2+ IN CEREBRAL-CORTEX NEURONS IS TRANSIENT IN IMMATURE CELLS BUT PERMANENT IN MATURE CELLS [J].

WAHL, P ;

SCHOUSBOE, A ;

HONORE, T ;

DREJER, J .

JOURNAL OF NEUROCHEMISTRY, 1989, 53 (04) :1316-1319

[5]

7727479

← 1 →