TRANSFORMING GROWTH FACTOR-ALPHA - AN ONCODEVELOPMENTAL GROWTH-FACTOR

被引：0
作者：
SALOMON, DS
KIM, N
SAEKI, T
CIARDIELLO, F
机构：
来源：
CANCER CELLS-A MONTHLY REVIEW | 1990年 / 2卷 / 12期
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-alpha-(TGF-alpha) is a 5-amino-acid mitogenic peptide that is structurally and, in some cases, functionally related to members of the epidermal growth factor (EGF) family of peptides. TGF-alpha is initially synthesized as a high-molecular-weight, glycosylated, membrane-associated precursor of approximately-160 amino acids. The low-molecular-weight TGF-alpha-peptide as well as the precursor are biologically active in a number of systems and can function as transforming proteins when overexpressed. TGF-alpha-binds to and activates the EGF receptor, and TGF-alpha and the EGF receptor are coexpressed in a number of human and rodent tumors and tumor cell lines - which suggests that TGF-alpha-can function as an autocrine or paracrine growth factor. TGF-alpha is transiently expressed in some fetal and adjacent maternal tissues during development and is also expressed in a number of adult tissues; this pattern of expression suggests that the growth factor is involved in several distinct physiological functions.
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页码：389 / 397
页数：9
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