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LACK OF EFFECT OF SHORT-TERM PASSIVE SMOKING ON THE METABOLIC DISPOSITION OF THEOPHYLLINE
被引:8
作者
:
CASTO, DT
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PEDIAT,SAN ANTONIO,TX 78284
CASTO, DT
SCHNAPF, BM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PEDIAT,SAN ANTONIO,TX 78284
SCHNAPF, BM
CLOTZ, MA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PEDIAT,SAN ANTONIO,TX 78284
CLOTZ, MA
机构
:
[1]
UNIV TEXAS,HLTH SCI CTR,DEPT PEDIAT,SAN ANTONIO,TX 78284
[2]
UNIV TEXAS,COLL PHARM,AUSTIN,TX 78712
来源
:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
|
1990年
/ 39卷
/ 04期
关键词
:
drug metabolism;
enzyme induction;
passive smoking;
Theophylline;
D O I
:
10.1007/BF00315418
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
To test the hypothesis that involuntary smoking can result in increased drug metabolism, five nonsmoking healthy male volunteers (21-36 y old) were enrolled in a study of single-dose theophylline pharmacokinetics before and after intense environmental tobacco smoke (ETS) exposure. Exposure was provided by spending 3 h/day for five consecutive days in a small room with a smoking apparatus that burned four cigarettes simultaneously, at a rate of 20 cigarettes/h. Measurement of urine cotinine concentration demonstrated that significant absorption from ETS occurred in all subjects. However, pre- and post-exposure pharmacokinetic parameters for theophylline did not differ significantly: VZ=0.438 vs 0.4401·kg-1; t1/2=9.19 vs 9.69 h; CL=34.4 vs 32.6 (ml·kg-1·h-1), respectively. Similarly, 24-hr urinary excretion of theophylline and its metabolites was unchanged by ETS exposure. We conclude that intense short-term passive smoking does not affect theophylline disposition. The possibility of chronic ETS exposure causing alterations in drug metabolism cannot be excluded. © 1990 Springer-Verlag.
引用
收藏
页码:399 / 402
页数:4
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