THE BLOCKING EFFECTS OF OMEGA-CONOTOXIN ON CA CURRENT IN BOVINE CHROMAFFIN CELLS

被引：50

作者：

HANS, M

ILLES, P

TAKEDA, K

机构：

[1] UNIV LOUIS PASTEUR STRASBOURG,PHARMACOL CELLULAIRE & MOLEC LAB,CNRS,URA 600,BP 24,F-67401 ILLKIRCH GRAFFENS,FRANCE

[2] UNIV FREIBURG,INST PHARMAKOL,W-7800 FREIBURG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1990年 / 114卷 / 01期

关键词：

Adrenal chromaffin cells; Ca channels; Secretion; Whole-cell recording; ω-Conotoxin;

D O I：

10.1016/0304-3940(90)90429-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of ω-conotoxin (ω-CgTX) on voltage-sensitive Ca currents (ICa) were studied in cultured bovine adrenal chromaffin cells. A maximal block of ICa of 40-50% was obtained with ω-CgTX in the μM range, and was independent of the holding potential. The onset of block was both concentration- and time-dependent. In bovine chromaffin cells, Ca channels, both sensitive and insensitive to ω-CgTX, appear to be present. © 1990.

引用

页码：63 / 68

页数：6

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