Antiulcer activity of aqueous extract of leaves of Madhuca indica J. F. Gmel against naproxen induced gastric mucosal injury in rats

Objective: To evaluate antiulcer potential of aqueous extract of Madhuca indica (M. indica) J. F. Gmel leaves in rats. Methods: Aqueous extract of M. indica J.F. Gmel leaves was tested at the dose of 100, 200 and 400 mg/kg, p.o. against naproxen (30 mg/kg, p.o) induced gastric ulcer. Omeprazole (30 mg kg, p.o.) was used as a positive standard. Ulcerated area was measured by Image J software. Various antioxidant parameter like SOD, GSH, MDA, MPO, NO and histamine were also determined. Results: After 4 week treatment period, desired aim was achieved using aqueous extract of plant of M. indica at the dose of 200 and 400 mg/kg, p.o. (P<0.01, P<0.001) showed significant reduction in ulcerated area and ulcer index as compared to control group. Omeprazole (30 mg/kg, p.o.) was more effective in reducing ulcerated area after 30 days treatment period. In addition, SOD, GSH, NO significantly increased; MDA, MPO content significantly lowered when compared with control group. Histamine content didn't show any significant change at all the three doses. Conclusions: Our finding suggests that aqueous extract of M. indica J.F. Gmel leaves is effective in gastric ulcer protection.