INDOLE-DERIVATIVES WITH ANTIMYCOBACTERIAL ACTIVITY

被引：16

作者：

MAHBOOBI, S

GROTHUS, G

MEINDL, W

机构：

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 02期

关键词：

D O I：

10.1002/ardp.19943270209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,3-Dinitro-2-(indol-3'-yl)-propanes 3 are synthesized by Michael reaction of nitromethane with the indolylnitroethenes 2. - Reaction of the aldehydes 4 and 10 with the benzylamines 12 as well as the reaction of the indolylal-kylamines 6a and 9a with the benzaldehydes 11 lead to Schiff bases which are reduced to N-benzyl-(indol-3-ylmethyl)-amines 13 and N-benzyl(indol-3-ylethyl)-amines 14, respectively; tert amines 16 are synthesized via the formamides 15, amines 18 are prepared according to Mannich. Inhibitory effects on Mycobacterium tuberculosis H 37 Ra are investigated, a structure-activity relationship is discussed.

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页码：105 / 114

页数：10

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