EFFECTS OF ACIDIC FIBROBLAST GROWTH-FACTOR ON HIPPOCAMPAL LONG-TERM POTENTIATION IN FASTED RATS

被引：29

作者：

HISAJIMA, H

SAITO, H

ABE, K

NISHIYAMA, N

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1992年 / 31卷 / 03期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; LONG-TERM POTENTIATION; DENTATE GYRUS;

D O I：

10.1002/jnr.490310319

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of human recombinant acidic fibroblast growth factor (haFGF) on long-term potentiation (LTP) and the increase of the spike amplitude induced by weak tetanic stimulation were investigated and compared with those of CS23 (modified human basic FGF) in the dentate gyrus of fasted and non-fasted rats. haFGF didn't influence the LTP induced by the tetanus of 100 pulses at 100 Hz in both 24 hr fasted and non-fasted rats. On the other hand, the tetanus of 20 pulses at 60 Hz significantly enhanced the amplitude of population spike and facilitated the generation of LTP by the i.c.v. injection of 10-mu-l of 20-40-mu-g/ml haFGF in 24 hr fasted rats but not in non-fasted rats. However, 40-mu-g/ml CS23 induced LTP when the tetanus of 20 pulses at 60 Hz was applied in both fasted and non-fasted states. These results suggest that haFGF might be one of the regulating factors of feeding and memory.

引用

页码：549 / 553

页数：5

共 29 条

[1] EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].