CHROMOSOMAL LOCALIZATION OF THE GENE FOR AA-TYPE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR (PDGFRA) IN HUMANS AND MICE

被引：16
作者：
HSIEH, CL
NAVANKASATTUSAS, S
ESCOBEDO, JA
WILLIAMS, LT
FRANCKE, U
机构：
[1] STANFORD UNIV,MED CTR,BECKMAN CTR MOLEC & GENET MED,HOWARD HUGHES MED INST,STANFORD,CA 94305
[2] STANFORD UNIV,MED CTR,DEPT GENET,STANFORD,CA 94305
[3] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143
来源：
CYTOGENETICS AND CELL GENETICS | 1991年 / 56卷 / 3-4期
关键词：
C-KIT; REGION; MOUSE; PROLIFERATION; ASSIGNMENT; ONCOGENE; KINASE; FAMILY; MAP;
D O I：
10.1159/000133076
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The full-length cDNA of the receptor for human AA-type platelet-derived growth factor (PDGF) was used to assign the PDGFRA gene to region q11 --> q21 of human chromosome 4 and to mouse Chromosome 5 by somatic cell hybrid analysis. Since the same region also contains the c-kit oncogene homolog KIT, we carried out pulsed-field gel electrophoresis to determine the physical distance between the two genes in human DNA. The two probes, when successively applied to the same filters, hybridized to a 450-kb EagI-fragment but not to other common restriction fragments. The genes are separated by at least one NotI, one XhoI, and one SalI site.
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页码：160 / 163
页数：4
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