FLOW CYTOMETRIC ANALYSIS OF DNA PLOIDY IN LARGE CLEAVED CELL LYMPHOMAS

被引：3

作者：

AINE, R

LEHTINEN, T

LEHTINEN, M

BLANCO, G

APAJASARKKINEN, M

LEINIKKI, P

ALAVAIKKO, M

机构：

[1] TAMPERE UNIV,CENT HOSP,DEPT ONCOL,TAMPERE,FINLAND

[2] UNIV OULU,CENT HOSP,DEPT RADIOTHERAPY,SF-90220 OULU 22,FINLAND

[3] UNIV OULU,CENT HOSP,DEPT PATHOL,SF-90220 OULU 22,FINLAND

[4] UNIV TAMPERE,DEPT BIOMED SCI,TAMPERE,FINLAND

[5] NATL HLTH INST,HELSINKI,FINLAND

来源：

HEMATOLOGICAL ONCOLOGY | 1990年 / 8卷 / 06期

关键词：

NON-HODGKINS LYMPHOMAS; FLOW CYTOMETRY; DNA ANEUPLOIDY; DNA INDEX; S-PHASE FRACTION; SURVIVAL;

D O I：

10.1002/hon.2900080606

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The results of nuclear DNA content analysis of a series of 28 patients with large cleaved follicular centre cell non-Hodgkin's lymphomas (NHL) are reported. DNA aneuploidy was found in 11 (39 per cent) cases. The DNA indices of the DNA-aneuploid peaks ranged from 1.14 to 2.28. Seven (25 per cent) cases were tetraploid. DNA ploidy was not associated with prognosis. The percentage of S phase cells (SPF) ranged from 2.0 to 30.5 per cent (median 5.1 per cent). Lymphoma patients with SPF higher than 9.7 per cent had a worse survival rate than patients with lymphoma with less than 9.7 per cent S phase cells but the difference did not reach statistical significance. The results of the DNA ploidy and SPFF were comparable to those of intermediate and high grade malignancy NHLs.

引用

页码：339 / 346

页数：8

共 26 条

[1]

AINE R, 1984, SCAND J HAEMATOL, V32, P475

[2]

ALAVAIKKO M, 1982, ACTA PATH MICRO IM A, V90, P241

[3] CLINICAL USEFULNESS AND REPRODUCIBILITY OF HISTOLOGIC SUBCLASSIFICATION OF ADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA [J].

ARMITAGE, JO ;

DICK, FR ;

PLATZ, CE ;

CORDER, MP ;

LEIMERT, JT .

AMERICAN JOURNAL OF MEDICINE, 1979, 67 (06) :929-934

[4] ANALYSIS OF PCP-DATA TO DETERMINE FRACTION OF CELLS IN VARIOUS PHASES OF CELL-CYCLE [J].

BAISCH, H ;

GOHDE, W ;

LINDEN, WA .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1975, 12 (01) :31-39

[5]

BARLOGIE B, 1983, CANCER RES, V43, P3983

[6]

BAUER KD, 1986, CANCER RES, V46, P3173

[7]

BLANCO G, 1986, ANTICANCER RES, V6, P267

[8]

CARBONE PP, 1971, CANCER RES, V31, P1860

[9]

CHRISTENSSON B, 1986, CANCER, V58, P1295, DOI 10.1002/1097-0142(19860915)58:6<1295::AID-CNCR2820580620>3.0.CO

[10]

2-H

← 1 2 3 →