Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia

被引：6

作者：

Couzigou, Celia ^{[1
,2
,3
]}

Gabriel, Frederic ^{[1
,2
,3
]}

Biteau, Nicolas ^{[1
,2
]}

Fitton-Ouhabi, Valerie ^{[1
,2
]}

Noel, Thierry ^{[1
,2
]}

Accoceberry, Isabelle ^{[1
,2
,3
]}

机构：

[1] Univ Bordeaux, UMR 5234, Microbiol Fondamentale & Pathogenicite, F-33000 Bordeaux, France

[2] CNRS, UMR 5234, Microbiol Fondamentale & Pathogenicite, F-33000 Bordeaux, France

[3] Ctr Hosp Univ Bordeaux, Lab Parasitol Mycol, F-33000 Bordeaux, France

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2014年 / 5卷

关键词：

Candida kefyr; Kluyveromyces marxianus; ERG11; Single nucleotide polymorphism; Azole resistance;

D O I：

10.1016/j.mmcr.2014.04.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid substitutions were identified: K151E, whose role in fluconazole resistance was already demonstrated in Candida albicans, and E123Q, a new substitution never described so far in azole-resistant Candida yeast. (C) 2014 The Authors. International Society for Human and Animal Mycology. Published by Elsevier B.V.

引用

页码：12 / 15

页数：4

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