A VERY MILD AND QUANTITATIVE OXIDATION OF CEPHALOSPORINS WITH DIMETHYLDIOXIRANE

被引：12
作者：
GUNDA, TE
TAMAS, L
SALYI, S
NEMES, C
SZTARICSKAI, F
机构：
[1] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY
[2] LAJOS KOSSUTH UNIV,DEPT PHARMACOL TECHNOL,H-4010 DEBRECEN,HUNGARY
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期
基金：
匈牙利科学研究基金会;
关键词：
D O I：
10.1016/0040-4039(95)01411-A
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cephalosporins 1-3 and Delta(2)-cephem 4 were oxidized in quantative yields to their sulfones with dimethyldioxirane. While in the case of 2-methylene-cephems (5,6) the exocyclic double bond oxidized simultaneously to the corresponding epoxide, the 3-vinyl derivative (8) or 3-methylene-cephems (7) gave selectively the corresponding vinyl sulfone.
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收藏
页码：7111 / 7114
页数：4
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