FUNCTIONAL MAPPING OF THE HUMAN VISUAL-CORTEX BY MAGNETIC-RESONANCE-IMAGING

被引:1291
作者
BELLIVEAU, JW
KENNEDY, DN
MCKINSTRY, RC
BUCHBINDER, BR
WEISSKOFF, RM
COHEN, MS
VEVEA, JM
BRADY, TJ
ROSEN, BR
机构
[1] MASSACHUSETTS GEN HOSP,CTR NMR,DEPT RADIOL,BOSTON,MA 02114
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
[3] MASSACHUSETTS GEN HOSP,CTR NMR,DEPT NEUROL,BOSTON,MA 02114
关键词
D O I
10.1126/science.1948051
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. This technique was used to generate the first functional magnetic resonance maps of human task activation, by using a visual stimulus paradigm. During photic stimulation, localized increases in blood volume (32 +/- 10 percent, n = 7 subjects) were detected in the primary visual cortex. Center-of-mass coordinates and linear extents of brain activation within the plane of the calcarine fissure are reported.
引用
收藏
页码:716 / 719
页数:4
相关论文
共 42 条
[1]   BRAIN IMAGING - APPLICATIONS IN PSYCHIATRY [J].
ANDREASEN, NC .
SCIENCE, 1988, 239 (4846) :1381-1388
[2]   TISSUE MEAN TRANSIT-TIME FROM DYNAMIC COMPUTED-TOMOGRAPHY BY A SIMPLE DECONVOLUTION TECHNIQUE [J].
AXEL, L .
INVESTIGATIVE RADIOLOGY, 1983, 18 (01) :94-99
[4]  
Belliveau J W, 1991, J Neuroimaging, V1, P36
[5]   FUNCTIONAL CEREBRAL IMAGING BY SUSCEPTIBILITY-CONTRAST NMR [J].
BELLIVEAU, JW ;
ROSEN, BR ;
KANTOR, HL ;
RZEDZIAN, RR ;
KENNEDY, DN ;
MCKINSTRY, RC ;
VEVEA, JM ;
COHEN, MS ;
PYKETT, IL ;
BRADY, TJ .
MAGNETIC RESONANCE IN MEDICINE, 1990, 14 (03) :538-546
[6]  
CAVINESS VS, 1989, BRAIN DEV-JPN, V11, P1
[7]   PERSPECTIVES ON COGNITIVE NEUROSCIENCE [J].
CHURCHLAND, PS ;
SEJNOWSKI, TJ .
SCIENCE, 1988, 242 (4879) :741-745
[8]   ULTRA-FAST IMAGING [J].
COHEN, MS ;
WEISSKOFF, RM .
MAGNETIC RESONANCE IMAGING, 1991, 9 (01) :1-37
[9]   MR CONTRAST DUE TO MICROSCOPICALLY HETEROGENEOUS MAGNETIC-SUSCEPTIBILITY - NUMERICAL SIMULATIONS AND APPLICATIONS TO CEREBRAL PHYSIOLOGY [J].
FISEL, CR ;
ACKERMAN, JL ;
BUXTON, RB ;
GARRIDO, L ;
BELLIVEAU, JW ;
ROSEN, BR ;
BRADY, TJ .
MAGNETIC RESONANCE IN MEDICINE, 1991, 17 (02) :336-347
[10]   STIMULUS RATE DEPENDENCE OF REGIONAL CEREBRAL BLOOD-FLOW IN HUMAN STRIATE CORTEX, DEMONSTRATED BY POSITRON EMISSION TOMOGRAPHY [J].
FOX, PT ;
RAICHLE, ME .
JOURNAL OF NEUROPHYSIOLOGY, 1984, 51 (05) :1109-1120