Defective lymphoproliferative responses and interleukin-2 production in chronic renal failure patients

被引：0
|
作者：
Krishnamurthy, G
Kher, V
Naik, S
机构：
[1] SANJAY GANDHI POSTGRAD INST MED SCI,DEPT IMMUNOL,LUCKNOW 226014,UTTAR PRADESH,INDIA
[2] SANJAY GANDHI POSTGRAD INST MED SCI,DEPT NEPHROL,LUCKNOW 226014,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF MEDICAL RESEARCH | 1995年 / 102卷
关键词：
anti-CD3; cytokines; early renal failure; end stage renal disease; haemodialysis; phytohaemagglutinin; uraemia;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cellular immune responses were evaluated in 12 early renal failure (ERP) patients who were not on maintenance haemodialysis, 43 end stage renal disease (ESRD) patients on haemodialysis (no) and 25 healthy volunteers. Peripheral blood mononuclear cells (PBMC) of ERF and ESRD patients on no had a significantly diminished lymphoproliferative responses to phytohaemagglutinin and a monoclonal antibody to the CD3 (anti-CD3) receptor on T-cells as compared to normals. The interleukin-2 (IL-2) production by the PBMC was also significantly reduced in renal failure patients as compared to normals. These data suggest that both IL-2 dependent and IL-2 independent T-cell functions are defective in renal failure patients.
引用
收藏
页码：281 / 286
页数：6
相关论文
共 50 条
  • [31] Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure
    Koryakova, N. N.
    Rozhdestvenskaya, E. D.
    Kazantseva, S. V.
    Bushueva, T. V.
    Valamina, I. E.
    TERAPEVTICHESKII ARKHIV, 2006, 78 (05) : 14 - 17
  • [32] Renal cell therapy is associated with dynamic and individualized responses in patients with acute renal failure
    Humes, HD
    Weitzel, WF
    Bartlett, RH
    Swaniker, FC
    Paganini, EP
    BLOOD PURIFICATION, 2003, 21 (01) : 64 - 71
  • [33] EVIDENCE THAT GRANULOSA-CELLS INHIBIT INTERLEUKIN-1-ALPHA AND INTERLEUKIN-2 PRODUCTION FROM FOLLICULAR LYMPHOMONOCYTES
    MACCIO, A
    MANTOVANI, G
    TURNU, E
    ARTINI, P
    CONTU, G
    SERRI, FG
    VOLPE, A
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1993, 10 (08) : 517 - 522
  • [34] NASAL MESSENGER-RNA EXPRESSION OF INTERLEUKIN-2, INTERLEUKIN-4, AND INTERLEUKIN-5 IN PATIENTS WITH ALLERGIC RHINITIS
    KARLSSON, MG
    DAVIDSSON, A
    VIALE, G
    GRAZIANI, D
    HELLQUIST, HB
    DIAGNOSTIC MOLECULAR PATHOLOGY, 1995, 4 (02) : 85 - 92
  • [35] Causes of Chronic Renal Failure among Iranian Hemodialysis Patients
    Malekmakan, Leila
    Haghpanah, Sezaneh
    Pakfetrat, Maryam
    Malekmakan, Alireza
    Khajehdehi, Parviz
    SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION, 2009, 20 (03) : 501 - 504
  • [36] Plasma Ceruloplasmin in Chronic Renal Failure Patients Undergoing Haemodialysis
    Ashok, K. J.
    Sajida, M. P.
    Joseph, S.
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2010, 4 (01) : 2058 - 2060
  • [37] Restless legs syndrome in chronic renal failure patients on dialysis
    van Tonder, Carin Behrens
    Joubert, Gina
    Moodley, Anand
    AFRICAN HEALTH SCIENCES, 2023, 23 (03) : 764 - 777
  • [38] Ocular findings in patients with chronic renal failure undergoing haemodialysis
    Vrabec, R
    Vatavuk, Z
    Pavlovic, D
    Sesar, A
    Cala, S
    Mandic, K
    Bucan, K
    COLLEGIUM ANTROPOLOGICUM, 2005, 29 : 95 - 98
  • [39] Nail changes in chronic renal failure patients under haemodialysis
    Salem, A.
    Al Mokadem, S.
    Attwa, E.
    El Raoof, S. Abd
    Ebrahim, H. M.
    Faheem, K. T.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2008, 22 (11) : 1326 - 1331
  • [40] Citalopram pharmacokinetics in patients with chronic renal failure and the effect of haemodialysis
    Spigset, O
    Hägg, S
    Stegmayr, B
    Dahlqvist, R
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2000, 56 (9-10) : 699 - 703
12345