HEAT-SHOCK PROTEINS AND JUVENILE CHRONIC ARTHRITIS

被引：0

作者：

DEGRAEFFMEEDER, ER ^{[1
]}

VANEDEN, W ^{[1
]}

RIJKERS, GT ^{[1
]}

PRAKKEN, BJ ^{[1
]}

ZEGERS, BJM ^{[1
]}

KUIS, W ^{[1
]}

机构：

[1] UNIV UTRECHT,FAC VET,DEPT INFECT DIS & IMMUNOL,UTRECHT,NETHERLANDS

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1993年 / 11卷

关键词：

HEAT SHOCK PROTEINS; JUVENILE CHRONIC ARTHRITIS; T-CELL IMMUNITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heat-shock proteins are a category of proteins that are synthesized under stressful conditions (such as increased temperatures) both by prokaryotic and eukaryotic cells. Heat-shock proteins are a major target of the immune response and thus can be considered dominant antigens. Under physiological circumstances the response to heat-shock proteins is considered to play a role in the overall defence against bacterial infections. An aberrant immune response against heat-shock proteins may lead to autoimmunity, as illustrated by adjuvant arthritis in Lewis rats. Current evidence also points towards a role of T cell immunity against heat-shock proteins in the development of human autoimmune diseases such as juvenile chronic arthritis.

引用

页码：S25 / S28

页数：4

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