METASTATIC HEPATOCELLULAR-CARCINOMA OF THE BREAST, SIMULATING GYNECOMASTIA - DIAGNOSIS BY FINE-NEEDLE ASPIRATION BIOPSY

被引：8

作者：

NAPPI, O ^{[1
]}

FERRARA, G ^{[1
]}

IANNIELLO, G ^{[1
]}

WICK, MR ^{[1
]}

机构：

[1] GEN CITY HOSP,DEPT PATHOL,BENEVENTO,ITALY

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1992年 / 8卷 / 06期

关键词：

HEPATIC NEOPLASMS; FINE-NEEDLE ASPIRATION; IMMUNOCYTOLOGY;

D O I：

10.1002/dc.2840080610

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hepatocellular carcinoma (HCC) may uncommonly present with distant metastasis in the absence of a documented neoplasm in the liver. The authors herein describe the case of a 60-year-old man with cirrhosis who developed unilateral enlargement of the breast and a subareolar mass. This problem was clinically thought to represent gynecomastia, but a mammary fine-needle aspiration biopsy demonstrated a malignant epithelial neoplasm composed of large granular amphophilic cells. Bile pigment was visualized in the tumor on aspirate smears and cell block preparations; immunostains showed reactivity for cytokeratin and alpha-feto-protein, but there was no positivity for epithelial membrane antigen, gross cystic disease fluid protein-15, vimentin, estrogen receptors, progesterone receptors, or S100 protein. These results indicated a diagnosis of metastatic HCC, which was subsequently confirmed by computed tomography of the abdomen.

引用

页码：588 / 592

页数：5

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