RECIPROCAL INVITRO INTERACTIONS BETWEEN HUMAN HERPESVIRUS-6 AND HIV-1 TAT

被引：0
|
作者：
DILUCA, D [1 ]
SECCHIERO, P [1 ]
BOVENZI, P [1 ]
ROTOLA, A [1 ]
CAPUTO, A [1 ]
MONINI, P [1 ]
CASSAI, E [1 ]
机构：
[1] UNIV FERRARA,INST MICROBIOL,VIA BORSARI 46,I-44100 FERRARA,ITALY
来源：
AIDS | 1991年 / 5卷 / 09期
关键词：
HUMAN HERPESVIRUS-6; HIV-1; TAT; LONG TERMINAL REPEAT TRANSACTIVATION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transactivation induced by human herpesvirus 6 (HHV-6) on the HIV-1 promoter was studied both in the presence and in the absence of the retroviral transactivator protein (Tat) constitutively expressed in Jurkat cells. Jurkat-tat cells were infected with HHV-6, transfected with a plasmid containing HIV-1 long terminal repeat (LTR)/chloramphenicol acetyltransferase (CAT), and CAT assays were performed. HHV-6 infection in the presence of Tat resulted in significantly higher LTR activation than that observed by Tat or HHV-6 alone, indicating that HHV-6 and Tat interact synergically. Furthermore, it was demonstrated that expression of HIV-1 lat inhibits HHV-6 replication, as shown by a 3.6-15.4-fold reduction in infectious yield. We suggest that HHV-6 could trigger HIV reactivation in HIV-seropositive patients which, in turn, could inhibit HHV-6 production.
引用
收藏
页码：1095 / 1098
页数：4
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