RECIPROCAL INVITRO INTERACTIONS BETWEEN HUMAN HERPESVIRUS-6 AND HIV-1 TAT

被引：0
|
作者：
DILUCA, D [1 ]
SECCHIERO, P [1 ]
BOVENZI, P [1 ]
ROTOLA, A [1 ]
CAPUTO, A [1 ]
MONINI, P [1 ]
CASSAI, E [1 ]
机构：
[1] UNIV FERRARA,INST MICROBIOL,VIA BORSARI 46,I-44100 FERRARA,ITALY
来源：
AIDS | 1991年 / 5卷 / 09期
关键词：
HUMAN HERPESVIRUS-6; HIV-1; TAT; LONG TERMINAL REPEAT TRANSACTIVATION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transactivation induced by human herpesvirus 6 (HHV-6) on the HIV-1 promoter was studied both in the presence and in the absence of the retroviral transactivator protein (Tat) constitutively expressed in Jurkat cells. Jurkat-tat cells were infected with HHV-6, transfected with a plasmid containing HIV-1 long terminal repeat (LTR)/chloramphenicol acetyltransferase (CAT), and CAT assays were performed. HHV-6 infection in the presence of Tat resulted in significantly higher LTR activation than that observed by Tat or HHV-6 alone, indicating that HHV-6 and Tat interact synergically. Furthermore, it was demonstrated that expression of HIV-1 lat inhibits HHV-6 replication, as shown by a 3.6-15.4-fold reduction in infectious yield. We suggest that HHV-6 could trigger HIV reactivation in HIV-seropositive patients which, in turn, could inhibit HHV-6 production.
引用
收藏
页码：1095 / 1098
页数：4
相关论文
共 50 条
  • [1] Human herpesvirus-6 reactivation in a longitudinal study of two HIV-1 infected patients
    Iuliano, R
    Trovato, R
    Lico, S
    Luppi, M
    Forastieri, G
    Barsanti, LA
    Pizzigallo, AM
    Mecocci, L
    Barozzi, P
    Torelli, G
    Mazzotta, F
    CeccheriniNelli, L
    JOURNAL OF MEDICAL VIROLOGY, 1997, 51 (04) : 259 - 264
  • [2] Reciprocal transactivation between HIV-1 and other human viruses
    White, Martyn K.
    Gorrill, Timothy S.
    Khalili, Kamel
    VIROLOGY, 2006, 352 (01) : 1 - 13
  • [3] The Ins and Outs of HIV-1 Tat
    Debaisieux, Solene
    Rayne, Fabienne
    Yezid, Hocine
    Beaumelle, Bruno
    TRAFFIC, 2012, 13 (03) : 355 - 363
  • [4] Reciprocal modulation of transcriptional activities between HIV-1 tat and MHC class II transactivator CIITA
    Okamoto, H
    Asamitsu, K
    Nishimura, H
    Kamatani, N
    Okamoto, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 279 (02) : 494 - 499
  • [5] Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions
    Raymond, Andrea D.
    Hasham, Muneer
    Tsygankov, Alexander Y.
    Henderson, Earl E.
    CURRENT HIV RESEARCH, 2007, 5 (01) : 79 - 86
  • [6] HIV-1 Tat endocytosis and retention in endolysosomes affects HIV-1 Tat-induced LTR transactivation in astrocytes
    Khan, Nabab
    Halcrow, Peter W.
    Afghah, Zahra
    Baral, Aparajita
    Geiger, Jonathan D.
    Chen, Xuesong
    FASEB JOURNAL, 2022, 36 (03)
  • [7] Inhibition of human immunodeficiency virus 1 (HIV-1) by variant B of human herpesvirus 6 (HHV-6)
    Bonura, F
    Perna, AM
    Vitale, F
    Villafrate, MR
    Viviano, E
    Guttadauro, R
    Mazzola, G
    Romano, N
    MICROBIOLOGICA, 1999, 22 (03): : 161 - 171
  • [8] Procedures for preparing biologically inactive, but immunogenic HIV-1 Tat protein (Tat Toroid) for human use
    Le Buanec, H
    Bizzini, B
    BIOMEDICINE & PHARMACOTHERAPY, 2000, 54 (01) : 41 - 44
  • [9] HIV-1 Tat: Role in Bystander Toxicity
    Ajasin, David
    Eugenin, Eliseo A.
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10
  • [10] Comparative analysis of HIV-1 Tat variants
    Pantano, S
    Carloni, P
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 58 (03) : 638 - 643
12345