EFFECT OF HIGH DIETARY NITRATE ON THE DISPOSITION OF SULFAMETHAZINE [4-AMINO-N-(4,6-DIMETHYL-2-PYRIMIDINYL)BENZENESULFONAMIDE] IN SWINE

Swine (58–74-kg initial weight) were fed a corn-soybean meal basal diet that contained 110 ppm sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; subnet] and 0, 10, 100, 500, or 1000 ppm nitrate. The concentrations of nitrite in the oral cavity and the concentrations of desa-minosulfamethazine [N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, DA-sulmet] in the blood were increased by feeding the highest levels of nitrate; however, 10 or 100 ppm of nitrate in the diet had little or no effect on nitrite and DA-sulmet concentrations in the oral cavity. Supplementing the diet with all levels of nitrate had little or no effect on the concentrations of sulmet and N4-Ac-sulmet in swine blood. © 1990, American Chemical Society. All rights reserved.