GENOMIC ANALYSIS OF THE 67-KDA LAMININ RECEPTOR IN NORMAL AND PATHOLOGICAL TISSUES - CIRCUMSTANTIAL EVIDENCE FOR RETROPOSON FEATURES

被引：20

作者：

BIGNON, C

ROUXDOSSETO, M

ZEIGLER, ME

MATTEI, MG

LISSITZKY, JC

WICHA, MS

MARTIN, PM

机构：

[1] SIMPSON MEM RES INST,DEPT INTERNAL MED,DIV HEMATOL ONCOL,ANN ARBOR,MI 48109

[2] GRP HOSP TIMONE,HOP ENFANTS,INSERM,U242,UNITE PHYSIOPATHOL CHROMOSOM,F-13385 MARSEILLE 5,FRANCE

来源：

GENOMICS | 1991年 / 10卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90336-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned two cDNAs for the human 67-kDa laminin receptor (LR). In the present report we show that these clones hybridize to many restriction fragments in Southern experiments in human. This particular pattern is accounted for by the presence of up to 16 and 21 copies of the laminin receptor gene per haploid genome in human and mouse, respectively. In contrast, a single gene copy is found in chicken. Chromosomal localization reveals four main loci: LAMRP1, laminin receptor pseudogene 1 (Chr 3); LAMRP2, laminin receptor pseudogene 2 (Chr 12); LAMRP3, laminin receptor pseudogene 3 (Chr 14); LAMRP4, laminin receptor pseudogene 4 (Chr X). Comparison of our experimental results to the known features of processed retropseudogenes enabled us to conclude that the LR gene belongs to a retroposon family in mammals. © 1991.

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页码：481 / 485

页数：5

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