NOREPINEPHRINE INCREASES CYCLIC-GMP IN ASTROCYTES BY A MECHANISM DEPENDENT ON NITRIC-OXIDE SYNTHESIS

被引：44

作者：

AGULLO, L

GARCIA, A

机构：

[1] UNIV AUTONOMA BARCELONA,INST BIOL FUNDAMENTAL V VILLAR PALASI,E-08193 BARCELONA,SPAIN

[2] UNIV AUTONOMA BARCELONA,DEPT BIOQUIM & BIOL MOLEC,BARCELONA,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1991年 / 206卷 / 04期

关键词：

NOREPINEPHRINE; CYCLIC GMP; ASTROCYTES; NITRIC OXIDE (NO);

D O I：

10.1016/0922-4106(91)90120-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Norepinephrine induces a rapid and concentration-dependent rise (EC50 = 1.21 +/- 0.33-mu-M) in cyclic GMP levels in astrocyte-enriched cultures from rat brain. The response is partially mediated by alpha-1-adrenoceptors since a marked inhibition is observed in the presence of prazosin while the beta-antagonist propranolol shows a smaller effect and the alpha-2-antagonist yohimbine is ineffective. L-N(G)-methylarginine, an inhibitor of nitric oxide synthesis from L-arginine, blocks the norepinephrine-induced cyclic GMP accumulation. This effect is reversed by L-arginine.

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页码：343 / 346

页数：4

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