Inhibitory effect of alpinate Oxyphyllae fructus extracts on Ang II-induced cardiac pathological remodeling-related pathways in H9c2 cardiomyoblast cells

被引：81
作者：
Chang, Yung-Ming [1 ,2 ]
Velmurugan, Bharath Kumar [3 ]
Kuo, Wei-Wen [4 ]
Chen, Yueh-Sheng [1 ]
Ho, Tsung-Jung [1 ,5 ]
Tsai, Chuan-Te [2 ]
Ye, Chi-Xin [3 ]
Tsai, Chang-Hai [6 ]
Tsai, Fuu-Jen [1 ,7 ]
Huang, Chih-Yang [1 ,3 ,8 ]
机构：
[1] China Med Univ, Sch Chinese Med, 91,Hsueh Shih Rd, Taichung 404, Taiwan
[2] IPT Biotechnol Co Ltd, Taichung, Taiwan
[3] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan
[4] China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan
[5] China Med Univ, Beigang Hosp, Chinese Med Dept, Beigang, Taiwan
[6] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan
[7] China Med Univ, Dept Pediat Med Res & Med Genet, Taichung, Taiwan
[8] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
来源：
BIOMEDICINE-TAIWAN | 2013年 / 3卷 / 04期
关键词：
alpinate Oxyphyllae fructus; Ang II; Gaq; hypertrophy; H9c2; cardiomyoblasts; IGF-II;
D O I：
10.1016/j.biomed.2013.05.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Our previous studies have demonstrated that Ang II induced IGF-II and IGF-II R via ERK and JNK signaling pathways and further induces cardiac cell apoptosis. Purpose: The present study investigates the protective role of alpinate Oxyphyllae fructus (AOF; Alpinia oxyphylla Miq) extracts on angiotensin II ( Ang II)- stimulated H9c2 cardiomyoblast cells. Methods: Western blotting was used to analyze the molecular mechanism involved in Ang II-treated H9c2 cells. Results: AOF inhibits cardiac hypertrophy, apoptosis, mitochondrial dysfunction, and cardiac remodeling in Ang II-treated H9c2 cells. Conclusion: All these data collectively suggest us that, AOF significantly inhibits Ang-II induced H9c2 cells apoptosis by suppressing the mitochondrial apoptotic pathway. Copyright (C) 2013, China Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
引用
收藏
页码：148 / 152
页数：5
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