Inhibitory effect of alpinate Oxyphyllae fructus extracts on Ang II-induced cardiac pathological remodeling-related pathways in H9c2 cardiomyoblast cells

被引：81

作者：

Chang, Yung-Ming ^{[1
,2
]}

Velmurugan, Bharath Kumar ^{[3
]}

Kuo, Wei-Wen ^{[4
]}

Chen, Yueh-Sheng ^{[1
]}

Ho, Tsung-Jung ^{[1
,5
]}

Tsai, Chuan-Te ^{[2
]}

Ye, Chi-Xin ^{[3
]}

Tsai, Chang-Hai ^{[6
]}

Tsai, Fuu-Jen ^{[1
,7
]}

Huang, Chih-Yang ^{[1
,3
,8
]}

机构：

[1] China Med Univ, Sch Chinese Med, 91,Hsueh Shih Rd, Taichung 404, Taiwan

[2] IPT Biotechnol Co Ltd, Taichung, Taiwan

[3] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan

[4] China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan

[5] China Med Univ, Beigang Hosp, Chinese Med Dept, Beigang, Taiwan

[6] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan

[7] China Med Univ, Dept Pediat Med Res & Med Genet, Taichung, Taiwan

[8] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan

来源：

BIOMEDICINE-TAIWAN | 2013年 / 3卷 / 04期

关键词：

alpinate Oxyphyllae fructus; Ang II; Gaq; hypertrophy; H9c2; cardiomyoblasts; IGF-II;

D O I：

10.1016/j.biomed.2013.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Our previous studies have demonstrated that Ang II induced IGF-II and IGF-II R via ERK and JNK signaling pathways and further induces cardiac cell apoptosis. Purpose: The present study investigates the protective role of alpinate Oxyphyllae fructus (AOF; Alpinia oxyphylla Miq) extracts on angiotensin II ( Ang II)- stimulated H9c2 cardiomyoblast cells. Methods: Western blotting was used to analyze the molecular mechanism involved in Ang II-treated H9c2 cells. Results: AOF inhibits cardiac hypertrophy, apoptosis, mitochondrial dysfunction, and cardiac remodeling in Ang II-treated H9c2 cells. Conclusion: All these data collectively suggest us that, AOF significantly inhibits Ang-II induced H9c2 cells apoptosis by suppressing the mitochondrial apoptotic pathway. Copyright (C) 2013, China Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：148 / 152

页数：5

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