RELEASE AND ACTIVATION OF PLATELET LATENT TGF-BETA IN BLOOD-CLOTS DURING DISSOLUTION WITH PLASMIN

被引：200

作者：

GRAINGER, DJ ^{[1
]}

WAKEFIELD, L ^{[1
]}

BETHELL, HW ^{[1
]}

FARNDALE, RW ^{[1
]}

METCALFE, JC ^{[1
]}

机构：

[1] NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892

来源：

NATURE MEDICINE | 1995年 / 1卷 / 09期

关键词：

D O I：

10.1038/nm0995-932

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor beta 1 (TGF-beta 1) is a platelet-derived cytokine involved in both normal wound healing and scarring. We show that human platelets contain two pools of latent TGF-beta 1, which constitute more than 95% of the total TGF-beta assayed in whole platelets. During clotting, one pool, the large latent TGF-beta complex consisting of latent TGF-beta binding protein (LTBP), the latency-associated peptide (LAP) and the 25-kD mature TGF-beta 1 dimer is released into the serum. A second pool, which contains LAP but not LTBP, is retained in the clot, but can be released by RGD peptide. When the clot is dissolved by plasmin this bound TGF-beta 1 is gradually activated and released. if similar mechanisms operate in vivo, the clot will act as a slow-release capsule of TGF-beta 1 activity during wound healing.

引用

页码：932 / 937

页数：6

共 28 条

[1] TRANSFORMING GROWTH-FACTOR-BETA AS A PREDICTOR OF LIVER AND LUNG FIBROSIS AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR ADVANCED BREAST-CANCER [J].