AMYLOID FORMATION BY SALMON-CALCITONIN

被引：25

作者：

GILCHRIST, PJ

BRADSHAW, JP

机构：

[1] Department of Preclinical Veterinary Sciences, University of Edinburgh, Edinburgh, Summerhall

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1182卷 / 01期

关键词：

AMYLOID FORMATION; AMYLOID PLAQUE; ALZHEIMERS DISEASE; CALCITONIN;

D O I：

10.1016/0925-4439(93)90160-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is demonstrated using three independent methods that salmon calcitonin can form amyloid fibrils in vitro. Large aggregates are shown to exhibit a blue-green birefringence in cross polarised light after staining with congo red. Individual fibrils were observed using electron microscopy. These fibrils are approx. 50-60 angstrom in diameter and up to 20000 angstrom in length and are similar in appearance to those observed in Alzheimer's disease. Finally, X-ray diffraction studies of the large aggregates reveal the cross-beta conformation characteristic of the monomers in the fibre.

引用

页码：111 / 114

页数：4

共 21 条

[1] PEPTIDES FROM THE CALCITONIN GENES - MOLECULAR-GENETICS, STRUCTURE AND FUNCTION [J].