POPULATION-GENETICS OF ABNORMAL-HEMOGLOBINS IN BURKINA-FASO, WEST AFRICA

被引：8

作者：

DEVOUCOUX, R

HURPIN, C

BAUDON, D

MOLEZ, JF

ROUX, JF

GUILLOUDBATAILLE, M

CARNEVALE, P

FEINGOLD, J

机构：

[1] ANTENNE ORSTOM,BREST,FRANCE

[2] INSERM,UNITE EPIDEMIOL GENET,F-75005 PARIS,FRANCE

来源：

ANNALS OF HUMAN BIOLOGY | 1991年 / 18卷 / 04期

关键词：

D O I：

10.1080/03014469100001612

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

The gene frequencies of haemoglobin A (HbA), HbS and HbC were studied in Burkina-Faso (BF) and in a neighbouring region of Niger, Ayorou. The frequency of HbS was higher in the Sahel region, (northern part of BF and Ayorou) than in the Savanna region. The reverse was true for the HbC gene. The major findings of this study are: (a) confirmation of a peak of HbC gene frequency in the central region of BF (Mossi plateau); (b) a possible negative correlation between the frequencies of HbS and HbC-Cavalli-Sforza and Bodmer have observed that this correlation is at a significantly different level from that expected because of the allelic relationship between HbS and HbC; (c) comparison with the data collected by Livingstone shows a modification in the fitness of the different genotypes in the last thirty years: AS individuals have a lower and AA and SS a higher fitness. Our data favour a partial selection relaxation in this region.

引用

页码：295 / 302

页数：8