Comparative Evaluation of Anti-Depressant Activity of Glycyrrhiza Glabra and Piper Nigrum Combination with Individual Drugs Effects and Standard Drug Imipramine in Mice

The main objective of this present study was to compare the anti-depressant property of Glycyrrhizin glabra and Piper nigrum in combination in swiss albino mice with Glycyrrhiza glabra and Piper nigrum individually and standard Imipramine. The doses of Glycyrrhizin glabra and Piper nigrum in suspension form and standard drug were administered into the animals for whole 4 weeks once daily.(Imipramine 20mg/kg, Glycyrrhizin glabra 150mg/kg and Piper nigrum 5mg/kg were individual drug doses and combination dose was Glycyrrhiza glabra 150mg/kg with Piper nigrum 5 mg/kg). The anti-depressant activity was performed using Force swim test and Tail suspension test as laboratory models. The anti-depressant activity was compared to standard drug imipramine. Combination drug therapy has better results than the individual dosage but standard showed optimum results. The results indicate that Glycyrrhiza glabra and Piper nigrum if given in combination is safe.