MUTAGENIC AND TOXIC ACTIVITY OF SOME JORDANIAN MEDICINAL-PLANTS

被引：7
|
作者：
ALKOFAHI, A
ALKHALIL, S
机构：
[1] JORDAN UNIV SCI & TECHNOL, FAC PHARM, DEPT MED CHEM & PHARMACOGNOSY, IRBID, JORDAN
[2] UNIV JORDAN, FAC PHARM, DEPT NAT PROD, AMMAN, JORDAN
来源：
INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1995年 / 33卷 / 01期
关键词：
PLANT EXTRACTS; BRINE SHRIMP; CYTOTOXICITY; MUTAGENICITY;
D O I：
10.3109/13880209509088149
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A total of 39 ethanol extracts of Jordanian plants were examined for cytotoxicity and mutagenicity. Among the tested plants, 8 extracts were active in the brine shrimp cytotoxicity bioassay with LC(50) values in the range of 2.5-870 mu g/ml. These positive extracts were further rested for their antirumor activity on human tumor cell lines in culture. Eminium spiculatum showed activity against a lung carcinoma line (A-549) with art ED(50) of 0.0793 mu g/ml. Regarding mutagenic effect, 16 of the extracts were active on Salmonella typhim-urium strains TA98 or TA102, and the extract of Podonosma oriantalis showed mutagenic activity in both strains.
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页码：61 / 64
页数：4
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