THE RENIN-ANGIOTENSIN SYSTEM AND NOCICEPTION IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：33

作者：

IRVINE, RJ

WHITE, JM

HEAD, RJ

机构：

[1] Department of Clinical and Experimental Pharmacology, University of Adelaide

[2] CSIRO Division of Human Nutrition, SA 5000, Kintore Avenue Adelaide

来源：

LIFE SCIENCES | 1995年 / 56卷 / 13期

关键词：

SPONTANEOUSLY HYPERTENSIVE RAT; ANALGESIA; CAPTOPRIL; LOSARTAN;

D O I：

10.1016/0024-3205(95)00043-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril (95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.

引用

页码：1073 / 1078

页数：6

共 16 条

[11] ACCESS OF PERIPHERALLY ADMINISTERED DUP-753 TO RAT-BRAIN ANGIOTENSIN-II RECEPTORS [J].