THE RENIN-ANGIOTENSIN SYSTEM AND NOCICEPTION IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：33
作者：
IRVINE, RJ
WHITE, JM
HEAD, RJ
机构：
[1] Department of Clinical and Experimental Pharmacology, University of Adelaide
[2] CSIRO Division of Human Nutrition, SA 5000, Kintore Avenue Adelaide
来源：
LIFE SCIENCES | 1995年 / 56卷 / 13期
关键词：
SPONTANEOUSLY HYPERTENSIVE RAT; ANALGESIA; CAPTOPRIL; LOSARTAN;
D O I：
10.1016/0024-3205(95)00043-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril (95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.
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收藏
页码：1073 / 1078
页数：6
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