BIOCOMPATIBILITY AND RESORBABILITY OF A POLYLACTIC ACID MEMBRANE FOR PERIODONTAL GUIDED TISSUE REGENERATION

被引:52
作者
ROBERT, P
MAUDUIT, J
FRANK, RM
VERT, M
机构
[1] FAC CHIRURG DENT,CTR RECH,4 RUE KIRSCHLEGER,F-67000 STRASBOURG,FRANCE
[2] FAC PHARM MONTPELLIER,CTR RECH BIOPOLYMERES ARTIFICELS,CNRS,URA 1465,F-34060 MONTPELLIER,FRANCE
关键词
BIOMEMBRANES; TISSUE REGENERATION; POLYLACTIC ACID; RESORPTION;
D O I
10.1016/0142-9612(93)90054-6
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The biocompatibility and degradation processes of biomembranes made of a mixture of a high molecular weight racemic polylactic acid (PLA50P) with 0, 10, 20 and 30% w/w racemic polylactic acid oligomers (PLA50p) were assessed for morphological changes in subcutaneous abdominal membrane implantations after 15, 21, 30 and 60 d in 45 Wistar rats. These membranes, prepared for periodontal guided tissue regeneration, showed excellent tissue tolerance without an inflammatory reaction. The higher the content in low molecular weight polylactic acid, the higher the degradation rate. At 60 d, the resorption process was almost complete. This process was initiated by outgrowths of short vascular septa, which developed into lobular networks infiltrating the membranes, which were progressively replaced by normal fibrous connective tissue.
引用
收藏
页码:353 / 358
页数:6
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