SYNAPTOSOMAL GLUTAMATE UPTAKE DECLINES PROGRESSIVELY IN THE SPINAL-CORD OF A MUTANT MOUSE WITH MOTOR-NEURON DISEASE

被引:31
作者
BATTAGLIOLI, G
MARTIN, DL
PLUMMER, J
MESSER, A
机构
[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,POB 509,ALBANY,NY 12201
[2] SUNY ALBANY,DEPT ENVIRONM HLTH & TOXICOL,ALBANY,NY 12222
[3] SUNY ALBANY,DEPT BIOMED SCI,ALBANY,NY 12222
关键词
GLUTAMATE UPTAKE; GABA UPTAKE; MOTOR NEURON DISEASE; SPINAL CORD;
D O I
10.1111/j.1471-4159.1993.tb03323.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has been suggested that the degeneration of motor neurons in amyotrophic lateral sclerosis is a consequence of excitotoxicity resulting from a loss of synaptosomal glutamate uptake. The role of synaptosomal glutamate uptake in the pathogenesis of motor neuron disease was studied in the Mnd mouse. Glutamate uptake in spinal-cord synaptosomes declined in parallel with the onset of behavioral deficits in Mnd mice but lagged considerably behind the appearance of pathology in motor neurons. Glutamate uptake did not decline significantly in corpus striatum, and GABA uptake did not change significantly in either spinal cord or striatum. The presence of pronounced histopathological changes before the loss of glutamate uptake suggests that the decline of glutamate uptake is a consequence rather than the primary cause of motor neuron disease in the Mnd mouse.
引用
收藏
页码:1567 / 1569
页数:3
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