INDUCTION OF DYSPNEA BY AEROSOL OF ENDOTHELIN-1 HISTAMINE OR METHACHOLINE IN THE CONSCIOUS GUINEA-PIG

被引：0

作者：

KOSHI, T ^{[1
]}

ETOH, Y ^{[1
]}

TORII, T ^{[1
]}

WADA, Y ^{[1
]}

HIRATA, M ^{[1
]}

OHKUCHI, M ^{[1
]}

OKABE, T ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 3, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 04期

关键词：

ENDOTHELIN-1; HISTAMINE; INDOMETHACIN; DYSPNEA; CONSCIOUS GUINEA PIG;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The inhalation of aerosol of endothelin-1 (ET-1) induced dyspneal behavior in conscious guinea pigs pretreated with histamine or methacholine inhalation, although it was not observed by the inhalation of ET-1 alone. The dyspneal response to the inhalation of ET-1/histamine was potently inhibited by indomethacin, but it was not affected by nifedipine or diphenhydramine.

引用

页码：1064 / 1065

页数：2

共 9 条

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