POLYMORPHISM IN PLASMODIUM-VIVAX MSA1 GENE - THE RESULT OF INTRAGENIC RECOMBINATIONS

被引：49
作者：
CHENG, Q
STOWERS, A
HUANG, TY
BUSTOS, D
HUANG, YM
RZEPCZYK, C
SAUL, A
机构：
[1] RES INST TROP MED, MANILA, PHILIPPINES
[2] GUANG XI INST PARASIT DIS CONTROL, NANNING, PEOPLES R CHINA
来源：
PARASITOLOGY | 1993年 / 106卷
基金：
美国国家卫生研究院; 英国医学研究理事会;
关键词：
POLYMORPHISM; PLASMODIUM-VIVAX; MSA1; PCR; SEQUENCE; RECOMBINATION;
D O I：
10.1017/S003118200006707X
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The diversity in a 925 bp portion of the Plasmodium vivax MSA1 gene in isolates from the Philippines, China, the Solomon Islands and Papua New Guinea was investigated. A total of 74 base pair changes was found in the amplified fragment from 18 isolates. Most of these changes were single or double base pair substitutions. In several regions, these point changes were tightly linked with one set always present or always absent in the different isolates. Seven such blocks were identified. These blocks were present in different combinations in the different isolates indicating that extensive intragenic recombination has occurred.
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页码：335 / 345
页数：11
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