OPIOIDS MODULATE INTERLEUKIN-1 PRODUCTION AND SECRETION BY BONE-MARROW MACROPHAGES

被引：63

作者：

APTE, RN

DURUM, SK

OPPENHEIM, JJ

机构：

[1] NCI, FREDERICK CANC RES FACIL, BIOL CARCINOGENESIS DEV PROGRAM RESOURCES INC, FREDERICK, MD 21701 USA

[2] NCI, FREDERICK CANC RES FACIL, BIOL RESPONSE MODIFIERS PROGRAM, MOLEC IMMUNOREGULAT LAB, FREDERICK, MD 21701 USA

来源：

IMMUNOLOGY LETTERS | 1990年 / 24卷 / 02期

关键词：

Bone marrow; Interleukin-1; Macrophage; Opioids;

D O I：

10.1016/0165-2478(90)90026-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study, we have assessed the effect of opioids (endorphins, enkephalins and neoendorphins) on production of IL-1 activity by bone-marrow-derived macrophages. None of the neuropeptides induced IL-1 production by itself. However, some of the opioids potentiated IL-1 production and release in macrophages concomitantly stimulated by lipopolysaccharide (LPS) or silica. LPS induced predominantly intracellular IL-1 activity, whereas most of the silica-induced IL-1 was released extracellularly. β-Endorphin, leucin-enkephalin (leu-enkephalin) and β-neoendorphin all potentiated both intracellular and extracellular release of IL 1 induced by either LPS or silica. In contrast, α-endorphin, methionine-enkephalin (metenkephalin) and α-neoendorphin did not influence IL-1 production or release. The potentiating effects of β-endorphin on LPS-induced IL-1 production/secretion were inhibited by naloxone, pointing to an involvement of opioid receptors. © 1990.

引用

页码：141 / 148

页数：8